Protease Inhibitors and Phosphatase Inhibitors
Apexbio Technology LLC GSK2606414, 50mg Cas No: 1337531-36-8 MFCD: MFCD25976926
GSK2606414 is a selective inhibitor of PERK with IC50 value of 0.4nM.[1]PERK (PRKR-like endoplasmic reticulum kinase or protein kinase R (PKR)-like endoplasmic reticulum kinase) is also known as EIF2AK3 (Eukaryotic translation initiation factor 2-alpha kinase 3). There are other sizes available. Please inqury us for quote.
Cayman Chemical Mps1tK InhIbItr 10mg
An inhibitor of Mps1/TTK (IC50 = 5.8 nM); inhibits Mps1 phosphorylation of KNL1 and increases the rate of mitosis at 100 nM; increases the number of missegregated chromosomes at 50 and 100 nM; inhibits colony formation of DLD1, HCT116, and U2OS cells (IC50s = 24.6, 20.1, and 20.6 nM, respectively)
Cayman Chemical SIRT12 InhIbItr IV 25mg
A cell-permeable inhibitor of SIRT1 (IC50 = 56 µM) and SIRT2 (IC50 = 59 µM); less effectively inhibits SIRT5 (IC50 >300 µM) and has no effect on class I and II HDACs; sensitizes H460 lung cancer cells to etoposide and paclitaxel; blocks a SIRT1-dependent hypoxic response in vivo
TARGETMOL CHEMICALS INC DARUNAVIR 50MG
Also available in 5 mg 10 mg 25 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. Darunavir (TMC114) is an HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS. Due to the emergence of ANTIVIRAL DRUG RESISTANCE when used alone it is administered in combination with other ANTI-HIV AGENTS. purity: 99%
Abcam PRL-3 Inhibitor I, 25MG
MW 485.2 Da, Purity =98%. A potent inhibitor of PRL-3, IC₅₀=0.9 μM. Sensitizes PRL-3-expressing cancer cells to chemotherapeutics. Inhibits dephosphorylation of tyrosine-783 of integrin β1 in BGC823 and SW480 cells. Reduces the invasive properties of mouse melanoma B16F10 cells in a cellular model.
The product is subject to the following: Abcam Restricted Use Statement
Gold Biotechnology Inc AEBSF 5 g
AEBSF is an irreversible serine protease inhibitor. AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin, kallikrein and thrombin. It inhibits by acylation of the active site of the enzyme. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, improved solubility in water and improved stability in aqueous solutions. AEBSF has been used in cell culture in concentrations of up to 0.25mM. Aqueous solutions are stable between pH 5-6; limited stability above pH 7.5.
Cayman Chemical Cdk9 InhIbItr 10mg
A Cdk9 inhibitor (IC50 = 39 nM); selective for Cdk9 over Cdk1-7 (IC50s = >1,000 nM for all); inhibits PRRSV replication in PRRSV-infected primary porcine alveolar macrophages at 6 to 200 nM
Medchemexpress LLC NSC668394 25mg | 382605-72-3 | 452.10 | C17H12Br2N2O3 | 25 MG
NSC668394 is a small-molecule inhibitor that blocks ezrin phosphorylation at Thr567. It is supplied as a high-purity solid for research use and is commonly used in cellular and biochemical studies of ezrin-mediated signaling and metastatic behavior.
- Inhibits ezrin Thr567 phosphorylation.
- High purity suitable for biochemical and cellular assays.
- Supplied as an orange to red solid for ease of handling.
- Available in small-quantity vials for laboratory research.
- For research use only; not for human or veterinary use.
Cayman Chemical FAK InhIbItr 14 100mg
A direct inhibitor of FAK1 autophosphorylation, blocking phosphorylation of Y397 (IC50 = 1 μM); no known significant effect on the activity of a range of other kinases; promotes cell detachment and inhibits cell adhesion of cells in culture; blocks tumor growth in vivo
Cayman Chemical Secreted AlkalIn Phosphatse
SEAP is commonly used as a reporter of gene expression. Compared to other conventional intracellular reporters such as CAT and firefly luciferase, SEAP has the advantage of being secreted from transfected cells into the culture medium. Cayman’s Secreted Alkaline Phosphatase Reporter Gene Assay Kit (Luminescence) provides a simple chemiluminescence method for the sensitive quantitation of SEAP in conditioned cell culture medium from transfected cells.
Cell Signaling Technology Protease/Phosphatase Inhibitor Cocktail (100X) 1 ml
Protease/Phosphatase Inhibitor Cocktail (100X) 1 ml
Echelon Biosciences Research Labs IC87114 5 mg
IC87114 is a specific inhibitor of PI 3-kinase (IC50 = 0.5 M) with >60-fold selectivity over other isoforms (IC50: = >100 M, = 75 M, = 29 M). It does not inhibit other protein kinases (p38MAPK, CHK1, cSrc, PKB, CK1, PKC, PKCII) at 10 uM. PI 3-K &delta has an important role in inflammation and inhibition has been shown to impair neutrophil migration. Administration of IC87114 in a mouse asthma model decreased allergic airway inflammation. This item is non returnable
Abcam Pepstatin A, aspartic protease inhibitor, 25MG
MW 685.9 Da, Purity >90%. Pepstatin A, aspartic protease inhibitor. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical Syk InhIbItr IIhydrochlorI 5mg
A cell-permeable, selective, and reversible inhibitor of Syk (IC50 = 41 nM); prevents FcεRI-mediated 5-HT release in RBL-2H3 cells in vitro (IC50 = 460 nM) and inhibits passive cutaneous anaphylaxis reactions in mice (ID50 = 13.2 mg/kg, s.c.)